Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.45 |
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079678 | 1.00 | ADRA2C (0.49) | ADRA2CCYP11B1CYP11B2CYP19A1CYP2A6 | |
| SCHEMBL8908887 | 0.85 | ADRA2C (0.51) | ADRA2CCYP11B1CYP11B2CYP19A1CYP2A6 | |
| SCHEMBL11078987 | 0.79 | TBXAS1 (0.65) | CYP11B1CYP11B2CYP19A1CYP2A6CYP2B6 | |
| SCHEMBL11078989 | 0.79 | TBXAS1 (0.65) | CYP11B1CYP11B2CYP19A1CYP2A6CYP2B6 | |
| SCHEMBL11635400 | 0.78 | ADRA2C (0.60) | ADRA2CCYP19A1TBXAS1CYP2C9CYP3A4 | |
| SCHEMBL11635397 | 0.78 | ADRA2C (0.60) | ADRA2CCYP19A1TBXAS1CYP2C9CYP3A4 | |
| SCHEMBL11635395 | 0.78 | ADRA2C (0.60) | ADRA2CCYP19A1TBXAS1CYP2C9CYP3A4 | |
| SCHEMBL11146930 | 0.76 | TBXAS1 (0.49) | ADRA2CTBXAS1CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL11382258 | 0.76 | ITGAL (0.51) | ADRA2CCYP11B1CYP11B2CYP19A1CYP2A6 | |
| SCHEMBL11146934 | 0.76 | TBXAS1 (0.49) | ADRA2CTBXAS1CYP2C9CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003732-B1 | IMIDAZOLE DERIVATIVES AND SALTS THEREOF, THEIR SYNTHESIS, AND PHARMACEUTICAL FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-10-19 | — | — | EP | claimed |
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | claimed |
| US-4357340-A | Imidazole derivatives and angina pectoris | BURROUGHS WELLCOME CO. (US) | 1982-11-02 | — | — | US | claimed |
| EP-0003732-A2 | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-09-05 | — | — | EP | claimed |
| US-4431815-A | CARDIOTONIC AND ANTISHOCK AGENTS; ANTICOAGULANTS | BURROUGHS WELLCOME CO. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4425354-A | CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0003732-B1 | IMIDAZOLE DERIVATIVES AND SALTS THEREOF, THEIR SYNTHESIS, AND PHARMACEUTICAL FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-10-19 | — | — | EP | disclosed |
| US-4405634-A | Imidazole derivatives for treating myocardial infarction | BURROUGHS WELLCOME CO. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | disclosed |
| US-4357340-A | Imidazole derivatives and angina pectoris | BURROUGHS WELLCOME CO. (US) | 1982-11-02 | — | — | US | disclosed |
| EP-0003732-A2 | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-09-05 | — | — | EP | disclosed |