Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082423 | 0.80 | PIM1 (0.40) | LIMK1HRH4MAPTRAB9AEGFR | |
| SCHEMBL11083135 | 0.78 | HRH4 (0.51) | LIMK1HRH4MAPTALDH1A1HPGD | |
| SCHEMBL24188653 | 0.78 | HRH4 (0.41) | LIMK1CDK5CDK5R1HRH4GPR3 | |
| SCHEMBL11149355 | 0.73 | LIMK1 (0.45) | LIMK1CDK5CDK5R1HRH4GPR3 | |
| SCHEMBL2914480 | 0.66 | MAPT (0.46) | HRH4MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL11799957 | 0.66 | LIMK1 (1.00) | LIMK1CDK5CDK5R1EGFR | |
| SCHEMBL9534468 | 0.66 | CDK5 (0.51) | LIMK1CDK5CDK5R1HRH4GPR3 | |
| SCHEMBL12170772 | 0.65 | MAPT (0.49) | HRH4GPR3MAPTALDH1A1KDM4E | |
| SCHEMBL14416828 | 0.65 | HRH4 (0.42) | HRH4MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL4699239 | 0.65 | HRH4 (0.44) | HRH4MAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431657-A | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-02-14 | — | — | US | claimed |
| US-4431657-A | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-02-14 | — | — | US | disclosed |