Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ILK | Q13418 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11098276 | 0.71 | LIMK1 (0.47) | CDK5CDK5R1LIMK1GPR3MAPT | |
| SCHEMBL11799957 | 0.68 | LIMK1 (1.00) | CDK5CDK5R1LIMK1EGFR | |
| SCHEMBL17022712 | 0.67 | TNKS (0.59) | CDK5CDK5R1LIMK1TNKSTNKS2 | |
| SCHEMBL9780135 | 0.67 | GPR3 (0.43) | CDK5CDK5R1LIMK1GPR3MAPT | |
| SCHEMBL29700327 | 0.66 | GPR3 (0.67) | CDK5CDK5R1LIMK1GPR3MAPT | |
| SCHEMBL430470 | 0.66 | GPR3 (0.67) | CDK5CDK5R1LIMK1GPR3MAPT | |
| SCHEMBL19119483 | 0.66 | LIMK1 (0.57) | CDK5CDK5R1LIMK1GPR3HRH4 | |
| SCHEMBL2497988 | 0.66 | HRH4 (0.53) | CDK5CDK5R1LIMK1HRH4MAPT | |
| SCHEMBL11077508 | 0.66 | LIMK1 (0.49) | CDK5CDK5R1LIMK1GPR3HRH4 | |
| SCHEMBL7096389 | 0.65 | MAPT (0.41) | CDK5CDK5R1LIMK1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347773-B1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-04-28 | — | — | EP | disclosed |
| US-4431657-A | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-02-14 | — | — | US | disclosed |
| US-4431657-A | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-02-14 | — | — | US | disclosed |
| US-4431657-A | Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-02-14 | — | — | US | disclosed |
| US-4018768-A | MICROBIOCIDES | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |