Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076991 | 0.84 | OPRM1 (0.50) | ADAM17SMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL11076988 | 0.84 | OPRM1 (0.50) | ADAM17SMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL15978559 | 0.84 | ADAM17 (0.57) | ADAM17OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL19585730 | 0.84 | ADAM17 (0.57) | ADAM17OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11078227 | 0.83 | OPRM1 (0.53) | ADAM17KDM4ESMN1; SMN2OPRM1 | |
| SCHEMBL11078230 | 0.83 | OPRM1 (0.53) | ADAM17KDM4ESMN1; SMN2OPRM1 | |
| SCHEMBL24738866 | 0.82 | HTR2C (0.48) | KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL29878836 | 0.82 | HTR2C (0.48) | KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10532283 | 0.81 | CACNA1F (0.47) | — | |
| SCHEMBL10831088 | 0.81 | SLC6A3 (0.49) | SMN1; SMN2OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435419-A | Method of treating depression using azabicyclohexanes | AMERICAN CYANAMID COMPANY (US) | 1984-03-06 | — | — | US | disclosed |
| US-4231935-A | ANXIOLYTICS AND ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-11-04 | — | — | US | disclosed |
| US-4196120-A | 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
| US-4131611-A | ANXIOLYTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1978-12-26 | — | — | US | disclosed |