Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.55 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11294468 | 1.00 | TAAR1 (0.68) | TAAR1MEN1KMT2AEPHX1SIGMAR1 | |
| SCHEMBL30624762 | 0.82 | SIGMAR1 (0.71) | TAAR1MEN1KMT2ASIGMAR1SLC18A2 | |
| Formetorex SCHEMBL2780459 | 0.81 | TAAR1 (1.00) | TAAR1MEN1KMT2AEPHX1SIGMAR1 | |
| Formetorex SCHEMBL14944822 | 0.81 | TAAR1 (1.00) | TAAR1MEN1KMT2AEPHX1SIGMAR1 | |
| Formetorex SCHEMBL1812509 | 0.81 | TAAR1 (1.00) | TAAR1MEN1KMT2AEPHX1SIGMAR1 | |
| SCHEMBL27925840 | 0.75 | EPHX1 (0.53) | EPHX1CYP1A2 | |
| SCHEMBL19285610 | 0.74 | TAAR1 (0.62) | TAAR1MEN1KMT2ASIGMAR1SLC18A2 | |
| SCHEMBL27884766 | 0.74 | ATM (0.56) | RAB9ALMNA | |
| SCHEMBL21243273 | 0.73 | SIGMAR1 (0.73) | TAAR1MEN1KMT2ASIGMAR1SLC18A2 | |
| SCHEMBL29257172 | 0.72 | EPHX1 (1.00) | TAAR1MEN1KMT2AEPHX1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061907-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1984-08-01 | — | — | EP | disclosed |
| EP-0061907-A1 | Secondary amines, their preparation, pharmaceutical compositions containing them and their use | BEECHAM GROUP PLC (GB) | 1982-10-06 | — | — | EP | disclosed |