Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078081 | 1.00 | MEN1 (0.52) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11091743 | 0.94 | NME2 (0.49) | MEN1KMT2ARAB9AMAPTPOLB | |
| SCHEMBL11091869 | 0.94 | NME2 (0.49) | MEN1KMT2ARAB9AMAPTPOLB | |
| SCHEMBL11086267 | 0.92 | RAB9A (0.50) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11086270 | 0.92 | RAB9A (0.50) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL21931881 | 0.88 | RAB9A (0.64) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11088016 | 0.83 | KMT2A (0.59) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11088020 | 0.83 | KMT2A (0.59) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11083663 | 0.82 | MEN1 (0.73) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL11083659 | 0.82 | MEN1 (0.73) | MEN1KMT2ARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |