Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NME2 | P22392 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091743 | 1.00 | NME2 (0.49) | NME2POLBMEN1KMT2AMAPT | |
| SCHEMBL11078112 | 0.94 | MEN1 (0.52) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11078081 | 0.94 | MEN1 (0.52) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11086270 | 0.86 | RAB9A (0.50) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11086267 | 0.86 | RAB9A (0.50) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11081932 | 0.84 | POLB (0.56) | NME2POLBMEN1KMT2AMAPT | |
| SCHEMBL11081930 | 0.84 | POLB (0.56) | NME2POLBMEN1KMT2AMAPT | |
| SCHEMBL11078056 | 0.83 | MEN1 (0.55) | NME2POLBMEN1KMT2AMAPT | |
| SCHEMBL11078059 | 0.83 | MEN1 (0.55) | NME2POLBMEN1KMT2AMAPT | |
| SCHEMBL11092091 | 0.83 | MEN1 (0.56) | NME2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |