SCHEMBL11078445

SCHEMBL11078445

CN1C(=O)C2CC2(c2ccccc2)C1=O

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 12/20 0.71
BACE1 P56817 2/20 0.40
BACE2 Q9Y5Z0 2/20 0.40
CTSD P07339 1/20 0.40
PRMT5 O14744 1/20 0.40
WDR77 Q9BQA1 1/20 0.40
CXCR3 P49682 1/20 0.40
REN P00797 1/20 0.39
APP P05067 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11076987 0.83 CYP19A1 (0.72) CYP19A1BACE1BACE2CTSDALDH1A1
SCHEMBL2779577 0.83 CYP19A1 (1.00) CYP19A1
SCHEMBL6002297 0.83 CYP19A1 (0.72) CYP19A1BACE1ALDH1A1
SCHEMBL6003692 0.82 CYP19A1 (0.57) CYP19A1BACE1BACE2CTSD
SCHEMBL10532320 0.81 CYP19A1 (0.68) CYP19A1ALDH1A1TSHRSMN1; SMN2
SCHEMBL10530117 0.81 CYP19A1 (0.68) CYP19A1
SCHEMBL11762657 0.80 CYP19A1 (0.48) CYP19A1BACE1BACE2CTSDPRMT5
SCHEMBL6003496 0.80 CYP19A1 (0.67) CYP19A1
SCHEMBL11079440 0.79 CYP19A1 (0.55) CYP19A1BACE1BACE2CTSDPRMT5
SCHEMBL11079959 0.79 CYP19A1 (0.74) CYP19A1CXCR3ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435419-A Method of treating depression using azabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1984-03-06 US disclosed
US-4231935-A ANXIOLYTICS AND ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-11-04 US disclosed
US-4196120-A 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
US-4131611-A ANXIOLYTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed