SCHEMBL11079440

SCHEMBL11079440

COc1cccc(C23CC2C(=O)N(C)C3=O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.55
PRMT5 O14744 1/20 0.49
WDR77 Q9BQA1 1/20 0.49
SIGMAR1 Q99720 3/20 0.47
KDM1A O60341 1/20 0.47
BACE1 P56817 3/20 0.46
BACE2 Q9Y5Z0 2/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
MAPT P10636 1/20 0.44
POLB P06746 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CTSD P07339 1/20 0.43
CTSE P14091 1/20 0.43
SLC6A4 P31645 2/20 0.42
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41
ADAM17 P78536 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4190618 0.85 CYP19A1 (0.57) CYP19A1PRMT5WDR77BACE1BACE2
SCHEMBL6003692 0.81 CYP19A1 (0.57) CYP19A1BACE1BACE2CTSDSLC6A4
SCHEMBL11078445 0.79 CYP19A1 (0.71) CYP19A1PRMT5WDR77BACE1BACE2
SCHEMBL11081708 0.79 SIGMAR1 (0.46) PRMT5WDR77SIGMAR1KDM1ABACE1
SCHEMBL6004350 0.77 CYP19A1 (0.53) CYP19A1BACE1BACE2CTSD
SCHEMBL30168029 0.75 MAPT (0.50) PRMT5WDR77SIGMAR1KDM1ABACE1
SCHEMBL11075149 0.75 CYP19A1 (0.50) CYP19A1SIGMAR1KDM1ABACE1KMT2A
SCHEMBL10995635 0.73 PRMT5 (0.43) PRMT5WDR77SIGMAR1KDM1ABACE1
SCHEMBL4190208 0.73 CYP19A1 (0.62) CYP19A1BACE1SLC6A4SLC6A2SLC6A3
SCHEMBL4188479 0.72 CYP19A1 (0.53) CYP19A1BACE1BACE2SMN1; SMN2CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435419-A Method of treating depression using azabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1984-03-06 US disclosed
US-4231935-A ANXIOLYTICS AND ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-11-04 US disclosed
US-4196120-A 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
US-4131611-A ANXIOLYTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed