SCHEMBL11079959

SCHEMBL11079959

CC(C)N1C(=O)C2CC2(c2ccccc2)C1=O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 12/20 0.74
CXCR3 P49682 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CYP2D6 P10635 1/20 0.36
MMP1 P03956 1/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
CACNA1F O60840 1/20 0.35
AR P10275 1/20 0.35
PDE4A P27815 1/20 0.35
SCN1A P35498 1/20 0.35
SCN4A P35499 1/20 0.35
SCN7A Q01118 1/20 0.35
CACNA1D Q01668 1/20 0.35
KCNH2 Q12809 1/20 0.35
CACNA1S Q13698 1/20 0.35
CACNA1C Q13936 1/20 0.35
SCN5A Q14524 1/20 0.35
SCN9A Q15858 1/20 0.35
SCN2A Q99250 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9410342 0.87 CYP19A1 (0.57) CYP19A1CYP2D6ALDH1A1HPGD
SCHEMBL10531988 0.85 CYP19A1 (1.00) CYP19A1
SCHEMBL10532357 0.80 CYP19A1 (0.67) CYP19A1ALDH1A1HPGD
SCHEMBL11078445 0.79 CYP19A1 (0.71) CYP19A1CXCR3SMN1; SMN2ALDH1A1
SCHEMBL11463156 0.74 CYP19A1 (0.48) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL8968925 0.74 CYP19A1 (0.82) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL8969269 0.72 CYP19A1 (0.62) CYP19A1SMN1; SMN2ALDH1A1
SCHEMBL11081758 0.72 CYP19A1 (0.76) CYP19A1ALDH1A1
SCHEMBL9410346 0.72 CYP19A1 (0.64) CYP19A1CXCR3SMN1; SMN2ALDH1A1HPGD
SCHEMBL11085254 0.67 CYP19A1 (0.51) CYP19A1SMN1; SMN2CYP2D6CACNA1FSCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435419-A Method of treating depression using azabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1984-03-06 US disclosed
US-4231935-A ANXIOLYTICS AND ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-11-04 US disclosed
US-4196120-A 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
US-4131611-A ANXIOLYTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed