Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.45 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090472 | 0.86 | TP53 (0.41) | MAPTTP53RBP4BRD4GAA | |
| SCHEMBL11089558 | 0.75 | TRPM5 (0.43) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL5674359 | 0.75 | CACNB4 (0.47) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11092005 | 0.72 | MAPT (0.40) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11087936 | 0.71 | HTR2C (0.40) | MAPTTP53RECQLRBP4CACNA1F | |
| SCHEMBL4113431 | 0.69 | CACNA1C (0.39) | MAPTTSHRCACNA1FCACNA1DCACNA1S | |
| SCHEMBL4113423 | 0.69 | CACNA1C (0.39) | MAPTTSHRCACNA1FCACNA1DCACNA1S | |
| SCHEMBL4113427 | 0.69 | CACNA1C (0.39) | MAPTTSHRCACNA1FCACNA1DCACNA1S | |
| SCHEMBL4110680 | 0.67 | CACNA1C (0.43) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL4110686 | 0.67 | CACNA1C (0.43) | MAPTCACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476133-A | CENTRAL NERVOUS SYSTEM DISORDERS | SHIONOGI & CO., LTD. (JP) | 1984-10-09 | — | — | US | disclosed |
| US-4374842-A | CENTRAL NERVOUS SYSTEM | SHIONOGI & CO., LTD. (JP) | 1983-02-22 | — | — | US | disclosed |