Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6907817 | 0.88 | ALDH1A1 (0.46) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL880444 | 0.75 | TP53 (0.59) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11090472 | 0.73 | TP53 (0.41) | MAPTTP53ALDH1A1HTR2CGAA | |
| SCHEMBL8922504 | 0.72 | DDB1 (0.50) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11079063 | 0.72 | MAPT (0.45) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11089558 | 0.70 | TRPM5 (0.43) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL4374687 | 0.70 | LMNA (0.39) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL15867659 | 0.69 | ALDH1A1 (0.42) | MAPTTP53ALDH1A1TNKS2LMNA | |
| SCHEMBL15870042 | 0.69 | BRD4 (0.45) | MAPTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL7271716 | 0.66 | PARP1 (0.53) | ALDH1A1MEN1KMT2AMAPK1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476133-A | CENTRAL NERVOUS SYSTEM DISORDERS | SHIONOGI & CO., LTD. (JP) | 1984-10-09 | — | — | US | disclosed |
| US-4374842-A | CENTRAL NERVOUS SYSTEM | SHIONOGI & CO., LTD. (JP) | 1983-02-22 | — | — | US | disclosed |