Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022665 | 0.84 | OPRM1 (0.44) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| Hydrochloric Acid SCHEMBL11098093 | 0.82 | OPRM1 (0.42) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| SCHEMBL11078172 | 0.82 | MAOA (0.33) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| Ethylene SCHEMBL11079292 | 0.81 | OPRM1 (0.41) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| SCHEMBL11076078 | 0.77 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| SCHEMBL11079009 | 0.75 | SLC6A4 (0.38) | SLC6A4SLC6A3SLC6A2HSD11B1KMT2A | |
| SCHEMBL11092002 | 0.74 | OPRM1 (0.44) | SLC6A4SLC6A2KMT2AMEN1OPRM1 | |
| SCHEMBL11076076 | 0.74 | MDM2 (0.42) | SLC6A4SLC6A3SLC6A2AVPR1AOPRM1 | |
| SCHEMBL22470125 | 0.73 | DRD2 (0.39) | SLC6A4SLC6A3SLC6A2MAOAMAOB | |
| SCHEMBL11075838 | 0.73 | SLC6A4 (0.37) | SLC6A4SLC6A3SLC6A2HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |