Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL957051 | 0.81 | MAPT (0.47) | GAAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL12425507 | 0.80 | POLB (0.56) | POLBGAAGFERKDM4EMEN1 | |
| SCHEMBL14036774 | 0.79 | GAA (0.51) | POLBGAAGFERKDM4EMEN1 | |
| SCHEMBL5014668 | 0.78 | POLB (0.59) | POLBGAAGFERMEN1ALDH1A1 | |
| SCHEMBL10603583 | 0.78 | P2RX3 (0.44) | POLBGAAGFERKDM4EALDH1A1 | |
| SCHEMBL15927485 | 0.77 | ALDH1A1 (0.37) | POLBGAAGFERALDH1A1TSHR | |
| SCHEMBL16526908 | 0.75 | TAAR1 (0.43) | GAAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL20969580 | 0.75 | TAAR1 (0.57) | POLBGAAGFERTAAR1 | |
| SCHEMBL14036532 | 0.75 | POLB (0.54) | POLBGAAGFERKDM4EMEN1 | |
| SCHEMBL6852792 | 0.74 | POLB (0.68) | POLBGAAGFERKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435397-A | ADRENERGIC BLOCKING AGENTS, 4-(3-ARYLOXY-2-HYDROXYPROPYL) SUBSTITUTED | NIPPON SHINYAKU CO., LTD. (JP) | 1984-03-06 | — | — | US | disclosed |