Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11384344 | 0.84 | ALOX5 (0.43) | SMN1; SMN2MEN1KMT2AALOX5CHRNB2 | |
| SCHEMBL17466005 | 0.82 | MEN1 (0.58) | SMN1; SMN2MEN1GAAKMT2AMAPT | |
| SCHEMBL8178062 | 0.79 | CHRNB2 (0.46) | SMN1; SMN2MEN1GAAKMT2AALOX5 | |
| SCHEMBL18734631 | 0.79 | CHRNB2 (0.46) | MEN1GAAKMT2AALOX5CHRNB2 | |
| SCHEMBL502194 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL6289274 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1GAAKMT2AALOX5 | |
| SCHEMBL10762809 | 0.78 | ALOX5 (0.45) | MEN1GAAKMT2AALOX5CHRNB2 | |
| SCHEMBL6384665 | 0.78 | ALOX5 (0.45) | SMN1; SMN2MEN1GAAKMT2AALOX5 | |
| SCHEMBL10772715 | 0.77 | ALOX5 (0.44) | SMN1; SMN2ALOX5CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4013434 | 0.76 | CHRNB2 (0.43) | MEN1GAAKMT2AALOX5CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002846-B1 | 3-THIENYLMALONIC ACIDS, THE CORRESPONDING DIESTERS AND THEIR PREPARATION | Océ-Andeno B.V. (NL) | 1984-05-23 | — | — | EP | disclosed |
| US-4262129-A | Preparation of a 3-thienylmalonic acid and the corresponding diesters | OCE-ANDENO B.V. (NL) | 1981-04-14 | — | — | US | disclosed |
| US-4252976-A | Process for the preparation of thiophenes | BEECHAM GROUP LIMITED (DE) | 1981-02-24 | — | — | US | disclosed |
| EP-0002846-A1 | 3-Thienylmalonic acids, the corresponding diesters and their preparation | Océ-Andeno B.V. (NL) | 1979-07-11 | — | — | EP | disclosed |