Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL830812 | 0.84 | MAPT (0.49) | MAPK1ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL6921788 | 0.80 | CACNA2D1 (0.40) | ALDH1A1ACHESMN1; SMN2MEN1KMT2A | |
| SCHEMBL15160572 | 0.76 | ALOX15 (0.52) | ALDH1A1ACHEMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10849420 | 0.73 | TDP1 (0.64) | ALDH1A1ACHEMAPTSMN1; SMN2HTT | |
| SCHEMBL6921832 | 0.72 | NPC1 (0.40) | ALDH1A1ACHESMN1; SMN2HTTKDM4E | |
| SCHEMBL14239084 | 0.72 | L3MBTL1 (0.48) | MAPK1ALDH1A1POLBACHEMAPT | |
| SCHEMBL3646786 | 0.72 | CRBN (0.66) | MAPK1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2050003 | 0.72 | KMT2A (0.60) | ALDH1A1POLBACHEMAPTSMN1; SMN2 | |
| SCHEMBL11092056 | 0.71 | ALDH1A1 (0.47) | MAPK1ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11092120 | 0.71 | ALDH1A1 (0.47) | MAPK1ALDH1A1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |