Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10338409 | 0.86 | KCNH2 (0.55) | PDE3BPDE3ADDB1CRBNCYP19A1 | |
| SCHEMBL11008299 | 0.81 | SRD5A1 (0.42) | PDE3BPDE3ADDB1CRBNCYP19A1 | |
| SCHEMBL11083179 | 0.80 | CYP11B1 (0.52) | PDE3BPDE3ACRBNCYP19A1PARP10 | |
| SCHEMBL9630168 | 0.79 | TDP2 (0.38) | CRBN | |
| SCHEMBL11112991 | 0.78 | CYP19A1 (0.44) | PDE3BPDE3ADDB1CRBNCYP19A1 | |
| SCHEMBL7450630 | 0.77 | PDE3B (0.61) | PDE3BPDE3ACRBN | |
| SCHEMBL11084887 | 0.76 | ALDH1A1 (0.46) | DDB1CRBN | |
| Hydrochloric Acid SCHEMBL10756530 | 0.76 | PDE3B (0.60) | PDE3BPDE3ACRBN | |
| SCHEMBL7467815 | 0.74 | KDM4E (0.43) | PDE3BPDE3ACYP19A1 | |
| SCHEMBL10755622 | 0.74 | PDE3B (0.62) | PDE3BPDE3ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | claimed |
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | disclosed |