Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080502 | 1.00 | TBXAS1 (0.53) | TBXAS1KMT2AMAPK1ALOX5HCAR2 | |
| SCHEMBL5849817 | 0.81 | KMT2A (0.56) | TBXAS1KMT2AMAPK1HCAR2RAB9A | |
| SCHEMBL5849815 | 0.81 | KMT2A (0.56) | TBXAS1KMT2AMAPK1HCAR2RAB9A | |
| SCHEMBL11077678 | 0.81 | CA12 (0.46) | TBXAS1KMT2AALOX5HCAR2RAB9A | |
| SCHEMBL11077680 | 0.81 | CA12 (0.46) | TBXAS1KMT2AALOX5HCAR2RAB9A | |
| SCHEMBL8920408 | 0.76 | MAPK1 (0.66) | TBXAS1KMT2AMAPK1ALOX5HCAR2 | |
| SCHEMBL8920416 | 0.76 | MAPK1 (0.66) | TBXAS1KMT2AMAPK1ALOX5HCAR2 | |
| SCHEMBL11075658 | 0.75 | ALDH1A1 (0.42) | KMT2AALOX5RAB9AALDH1A1HTT | |
| SCHEMBL11124268 | 0.75 | KMT2A (0.53) | TBXAS1KMT2AMAPK1RAB9AALDH1A1 | |
| SCHEMBL11124265 | 0.75 | KMT2A (0.53) | TBXAS1KMT2AMAPK1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039989-B1 | PYRIMIDONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-08-29 | — | — | EP | disclosed |
| US-4388317-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-06-14 | — | — | US | disclosed |
| EP-0039989-A1 | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-11-18 | — | — | EP | disclosed |