Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256388 | 0.88 | NPY5R (0.38) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10945205 | 0.87 | C1R (0.41) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11082598 | 0.83 | TSHR (0.51) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11083592 | 0.78 | HDAC3 (0.40) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11081405 | 0.76 | ADRA2A (0.37) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11081892 | 0.75 | TSHR (0.39) | C1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11079956 | 0.75 | POLB (0.43) | LRRK2JAK2GAALMNAMEN1 | |
| SCHEMBL11089831 | 0.75 | NPY5R (0.41) | HDAC3HDAC1HDAC2HDAC6LRRK2 | |
| SCHEMBL10938067 | 0.75 | NR1I2 (0.39) | C1RMEN1KMT2A | |
| SCHEMBL10936710 | 0.70 | C1R (0.43) | C1RADRA2AADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | claimed |
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |