Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076637 | 0.83 | SMN1; SMN2 (0.55) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL11078900 | 0.82 | NPC1 (0.60) | LMNAMEN1KMT2ASMN1; SMN2HIF1A | |
| SCHEMBL11072591 | 0.80 | BCHE (0.58) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL8940750 | 0.79 | ROCK2 (0.44) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL11083219 | 0.76 | NT5E (0.60) | LMNAMEN1KMT2AROCK2ROCK1 | |
| SCHEMBL13588772 | 0.74 | MDM2 (0.55) | LMNAMEN1KMT2AMDM2ROCK2 | |
| Pinacidil Anhydrous SCHEMBL9271625 | 0.72 | ABCC9 (0.56) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| Pinacidil Anhydrous SCHEMBL2131829 | 0.72 | ABCC9 (0.56) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| Pinacidil Anhydrous SCHEMBL9275528 | 0.72 | ABCC9 (0.56) | LMNAMEN1POLBKMT2ASMN1; SMN2 | |
| Pinacidil Anhydrous SCHEMBL65788 | 0.72 | ABCC9 (0.56) | LMNAMEN1POLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119428-A2 | Biscarboxamides for treating diseases, and process for their preparation | BAYER AG (DE) | 1984-09-26 | — | — | EP | disclosed |