Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016431 | 0.91 | KDM4E (0.43) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL11486647 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1ATMHTTNPC1 | |
| SCHEMBL11085738 | 0.84 | KDM4E (0.42) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL7831700 | 0.83 | KDM4E (0.45) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL4159068 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1ATMHTTNPC1 | |
| SCHEMBL8560175 | 0.80 | HTT (0.41) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL8878641 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1ATMHTTIL2 | |
| SCHEMBL11491135 | 0.76 | KDM4E (0.47) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL498998 | 0.76 | KDM4E (0.44) | KDM4EHPGDALDH1A1ATMHTT | |
| SCHEMBL655887 | 0.76 | HPGD (0.46) | KDM4EHPGDALDH1A1ATMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434100-A | TRANQUILIZING, ANTICONVULSANTS, ANXIOLYTIC | CIBA-GEIGY CORPORATION (US) | 1984-02-28 | — | — | US | disclosed |
| US-4356176-A | TRANQUILIZERS, ANTICONVULSANT | CIBA-GEIGY CORPORATION (US) | 1982-10-26 | — | — | US | disclosed |
| US-4315926-A | ANXIOLYTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-02-16 | — | — | US | disclosed |