Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075646 | 0.85 | KMT2A (0.59) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL11074705 | 0.81 | KMT2A (0.58) | NPC1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL13754270 | 0.79 | ALDH1A1 (0.67) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL8970981 | 0.79 | PTK2 (0.70) | NPC1RAB9ASMN1; SMN2AHRMEN1 | |
| SCHEMBL11081421 | 0.78 | NPSR1 (0.53) | KMT2AGAAHDAC8HDAC6 | |
| SCHEMBL413038 | 0.77 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2POLBAHR | |
| SCHEMBL5184066 | 0.77 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2POLBAHR | |
| SCHEMBL11078859 | 0.76 | HDAC1 (0.59) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL7300821 | 0.75 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2POLBAHR | |
| SCHEMBL20228918 | 0.73 | MAPT (0.76) | NPC1RAB9ASMN1; SMN2POLBAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119428-A2 | Biscarboxamides for treating diseases, and process for their preparation | BAYER AG (DE) | 1984-09-26 | — | — | EP | disclosed |