Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088146 | 1.00 | SLC18A3 (0.45) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL11084008 | 1.00 | SLC18A3 (0.45) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL12716991 | 0.90 | SLC18A3 (0.48) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL296401 | 0.90 | SIGMAR1 (0.44) | SIGMAR1NPY1RHTTNPY2R | |
| SCHEMBL1318062 | 0.85 | LTA4H (0.52) | SIGMAR1LTA4HNPY1RHTTNPY2R | |
| SCHEMBL10895325 | 0.83 | SLC18A3 (0.53) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL11086965 | 0.83 | SLC18A3 (0.53) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL11087006 | 0.83 | SLC18A3 (0.53) | SLC18A3SIGMAR1LTA4HNPY1RHTT | |
| SCHEMBL12716512 | 0.77 | SIGMAR1 (0.46) | SIGMAR1LTA4HALDH1A1 | |
| SCHEMBL25053002 | 0.75 | CYP1A2 (0.47) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4480099-A | Decahydroquinolyl benzamides | BEECHAM GROUP P.L.C. (GB) | 1984-10-30 | — | — | US | disclosed |
| EP-0068699-A1 | Decahydroquinolyl benzamides, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-01-05 | — | — | EP | disclosed |