Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11086965 | 1.00 | SLC18A3 (0.53) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL10895325 | 1.00 | SLC18A3 (0.53) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL11020677 | 0.89 | SIGMAR1 (0.53) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL11015522 | 0.89 | SIGMAR1 (0.53) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL1318062 | 0.85 | LTA4H (0.52) | SIGMAR1ALDH1A1LTA4HNPY1RHTT | |
| SCHEMBL11088146 | 0.83 | SLC18A3 (0.45) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL11084008 | 0.83 | SLC18A3 (0.45) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL11084006 | 0.83 | SLC18A3 (0.45) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL12716991 | 0.78 | SLC18A3 (0.48) | SLC18A3SIGMAR1ALDH1A1LTA4HNPY1R | |
| SCHEMBL1844987 | 0.75 | ALDH1A1 (0.56) | SIGMAR1ALDH1A1GBA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4480099-A | Decahydroquinolyl benzamides | BEECHAM GROUP P.L.C. (GB) | 1984-10-30 | — | — | US | disclosed |
| EP-0068699-A1 | Decahydroquinolyl benzamides, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-01-05 | — | — | EP | disclosed |