Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129375 | 0.82 | MAPT (0.68) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL1018418 | 0.81 | MAPT (0.66) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL11343355 | 0.81 | MAPT (0.66) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL11208230 | 0.79 | MAPT (1.00) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL10624873 | 0.75 | MAPT (0.58) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL8215174 | 0.74 | GAA (1.00) | MAPTGAAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3192014 | 0.74 | LMNA (0.77) | GAASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL1256515 | 0.74 | MAPT (0.57) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL28194366 | 0.74 | MAPT (0.57) | MAPTGAAALDH1A1TP53TDP1 | |
| SCHEMBL1750909 | 0.74 | CA12 (0.58) | MAPTGAAALDH1A1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0058779-B1 | CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1984-09-19 | — | — | EP | claimed |