Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074799 | 0.87 | — | — | |
| SCHEMBL6581667 | 0.83 | GABBR2 (0.51) | ALDH1A1TP53MEN1KMT2A | |
| SCHEMBL11078276 | 0.79 | DCAF1 (0.43) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14580268 | 0.75 | MEN1 (0.45) | ALDH1A1TP53MEN1KMT2A | |
| SCHEMBL16971108 | 0.75 | TSHR (0.44) | ALDH1A1MEN1POLBKMT2AKDM4E | |
| SCHEMBL11082454 | 0.75 | ALDH1A1 (0.39) | ALDH1A1TP53MEN1POLBKMT2A | |
| SCHEMBL523877 | 0.75 | GABBR2 (0.59) | MEN1KMT2AMAPT | |
| SCHEMBL10969727 | 0.74 | ALDH1A1 (0.41) | ALDH1A1TP53MEN1POLBKMT2A | |
| SCHEMBL11079515 | 0.74 | TNF (0.55) | ALDH1A1 | |
| SCHEMBL11079919 | 0.74 | TSHR (0.44) | ALDH1A1TP53MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |