SCHEMBL11087273

SCHEMBL11087273

COC(=O)Nc1nc2cc(S)ccc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 9/20 0.53
CYP1A2 P05177 6/20 0.53
HIF1A Q16665 5/20 0.53
SMN1; SMN2 Q16637 5/20 0.53
KDR P35968 3/20 0.53
ALDH1A1 P00352 3/20 0.53
ABL1 P00519 2/20 0.53
CYP2C9 P11712 2/20 0.53
HTT P42858 2/20 0.53
CYP2C19 P33261 1/20 0.53
ABCC4 O15439 1/20 0.53
USP2 O75604 1/20 0.53
TUBB4A P04350 6/20 0.52
TUBB P07437 6/20 0.52
TUBA3C P0DPH7 6/20 0.52
TUBA1B P68363 6/20 0.52
TUBA4A P68366 6/20 0.52
TUBB4B P68371 6/20 0.52
TUBB3 Q13509 6/20 0.52
TUBB2A Q13885 6/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28601663 0.89 LMNA (0.63) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL11096138 0.87 TUBB4A (0.48) LMNACYP1A2HIF1ASMN1; SMN2HTT
SCHEMBL31265132 0.86 TUBB4A (0.61) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL11402160 0.84 TUBB4A (0.60) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL5035998 0.84 LMNA (0.54) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL5351438 0.83 LMNA (0.53) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL11171719 0.83 NPC1 (0.55) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL10727499 0.82 LMNA (0.55) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL11366152 0.82 LMNA (0.62) LMNACYP1A2HIF1ASMN1; SMN2KDR
SCHEMBL6320497 0.82 LMNA (0.62) LMNACYP1A2HIF1ASMN1; SMN2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113186570-B Piston rod surface treatment process 江苏新合益机械有限公司 2021-12-28 CN claimed
CN-113186570-A Piston rod surface treatment process 江苏新合益机械有限公司 2021-07-30 CN claimed
CN-113186570-B Piston rod surface treatment process 江苏新合益机械有限公司 2021-12-28 CN disclosed
CN-113186570-A Piston rod surface treatment process 江苏新合益机械有限公司 2021-07-30 CN disclosed
US-20130303782-A1 PROCESS FOR PREPARATION OF ALBENDAZOLE SEQUENT SCIENTIFIC LIMITED (IN) 2013-11-14 US disclosed
US-4487936-A Preparation of alkylthiobenzimidazoles CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1984-12-11 US disclosed
EP-0031473-B1 PROCESS FOR PREPARING 2-((ALKOXYCARBONYL)-AMINO)-5-(ALKYLTHIO)-1H-BENZIMIDAZOLES CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1984-05-30 EP disclosed
US-4368328-A ANTHELMINTICS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1983-01-11 US disclosed
EP-0031473-A1 Process for preparing 2-((alkoxycarbonyl)-amino)-5-(alkylthio)-1H-benzimidazoles CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1981-07-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130303782-A1 PROCESS FOR PREPARATION OF ALBENDAZOLE CPS1, PNPO, NAT1 LMNA 4083/4885CYP1A2 101/4885HIF1A 4277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.