Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892209 | 0.80 | MAPT (0.52) | HDAC8SMN1; SMN2KDM4ERAB9ALMNA | |
| SCHEMBL11021664 | 0.79 | MAOB (0.36) | GRM5SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL10372228 | 0.78 | NPC1 (0.55) | SMN1; SMN2KDM4ERAB9ALMNANPC1 | |
| SCHEMBL11074319 | 0.77 | CSNK2A2 (0.59) | SMN1; SMN2RAB9ALMNANPC1ALDH1A1 | |
| SCHEMBL11105640 | 0.76 | KDM4E (0.60) | SMN1; SMN2KDM4ERAB9ALMNANPC1 | |
| SCHEMBL11415277 | 0.75 | CFTR (0.37) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL976167 | 0.75 | HDAC8 (0.59) | HDAC1HDAC8HDAC6SMN1; SMN2KDM4E | |
| SCHEMBL516118 | 0.75 | ALOX5 (0.52) | HDAC1HDAC8HDAC6KDM4ELMNA | |
| SCHEMBL10371019 | 0.75 | TSHR (0.54) | SMN1; SMN2KDM4ERAB9ALMNANPC1 | |
| SCHEMBL2662445 | 0.74 | ALPL (0.61) | SMN1; SMN2KDM4ERAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4432986-A | N-(TETRAZOL-5-YL)-(DIBENZOTHIOPHENE-, OR DIBENZOFURAN-, OR 1,3-BEZODIOXOLE-, OR NAPHTHALENE-)-4-CARBOXAMIDE | RIKER LABORATORIES, INC. (US) | 1984-02-21 | — | — | US | claimed |
| US-4432986-A | N-(TETRAZOL-5-YL)-(DIBENZOTHIOPHENE-, OR DIBENZOFURAN-, OR 1,3-BEZODIOXOLE-, OR NAPHTHALENE-)-4-CARBOXAMIDE | RIKER LABORATORIES, INC. (US) | 1984-02-21 | — | — | US | disclosed |