Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976167 | 0.87 | HDAC8 (0.59) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL6238717 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EGAAMAPTMAOB | |
| SCHEMBL28084237 | 0.83 | ALDH1A1 (0.59) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL4586057 | 0.83 | ALOX5 (0.48) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL783749 | 0.81 | NR4A1 (0.50) | ALOX5ALDH1A1KDM4EMAOBGLA | |
| SCHEMBL22645256 | 0.80 | MAPT (0.51) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL14825579 | 0.79 | ALOX5 (0.48) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL24008857 | 0.79 | CAPN1 (0.44) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL8820480 | 0.79 | ALOX5 (0.48) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 | |
| SCHEMBL516174 | 0.79 | KDM4E (0.53) | ALOX5HDAC8HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-02-02 | — | — | US | disclosed |
| WO-2010086279-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | CHRNA10, CHRNA6, CHRNA7 | ALOX5 1931/4885HDAC8 2677/4885HDAC1 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.