Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 7/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288733 | 0.88 | MAOB (0.42) | MAOBHRH3ACHEMAOA | |
| Hydrochloric Acid SCHEMBL11092182 | 0.88 | MAOB (0.42) | MAOBHRH3ACHEMAOA | |
| Bromide SCHEMBL11089271 | 0.86 | MAOB (0.40) | MAPTMAOBHRH3ACHEMAOA | |
| Bromide SCHEMBL11090702 | 0.86 | MAOB (0.39) | MAOBHRH3ACHEMAOA | |
| Hydrochloric Acid SCHEMBL11094001 | 0.84 | MAOB (0.41) | MAOBCA12CA9HRH3ACHE | |
| Bromide SCHEMBL11180051 | 0.83 | MAOB (0.38) | MAPTMAOBHRH3ACHEMAOA | |
| Bromide SCHEMBL11186218 | 0.83 | AR (0.40) | MAOBHRH3ACHEDRD4MAOA | |
| Hydrochloric Acid SCHEMBL11096484 | 0.83 | ACHE (0.41) | MAOBCA12CA9HRH3ACHE | |
| Bromide SCHEMBL11171168 | 0.81 | MAOB (0.42) | MAOBHRH3ACHEMAOA | |
| Hydrochloric Acid SCHEMBL11180874 | 0.78 | MAOB (0.41) | MAOBHRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |