Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 13/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288733 | 0.93 | MAOB (0.42) | MAOBMAOAACHEHRH3AR | |
| Hydrochloric Acid SCHEMBL11092182 | 0.92 | MAOB (0.42) | MAOBMAOAACHEHRH3AR | |
| Bromide SCHEMBL11090702 | 0.90 | MAOB (0.39) | MAOBMAOAACHEHRH3AR | |
| Bromide SCHEMBL11180051 | 0.89 | MAOB (0.38) | MAOBMAOAACHEHRH3KDM4E | |
| Hydrochloric Acid SCHEMBL11094001 | 0.88 | MAOB (0.41) | MAOBMAOAACHEHRH3 | |
| Bromide SCHEMBL11186218 | 0.87 | AR (0.40) | MAOBMAOAACHEHRH3AR | |
| Hydrochloric Acid SCHEMBL11096484 | 0.87 | ACHE (0.41) | MAOBMAOAACHEHRH3 | |
| Bromide SCHEMBL11088035 | 0.86 | MAPT (0.45) | MAOBMAOAACHEHRH3MAPT | |
| Bromide SCHEMBL11171168 | 0.85 | MAOB (0.42) | MAOBMAOAACHEHRH3 | |
| Hydrochloric Acid SCHEMBL11180874 | 0.82 | MAOB (0.41) | MAOBACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |