Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.41 |
| ▸ | BCHE | P06276 | 6/20 | 0.41 |
| ▸ | MAOB | P27338 | 7/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11094001 | 0.99 | MAOB (0.41) | ACHEBCHEMAOBMAOAAHR | |
| Hydrochloric Acid SCHEMBL11092182 | 0.93 | MAOB (0.42) | ACHEBCHEMAOBMAOAHRH3 | |
| Bromide SCHEMBL11171168 | 0.92 | MAOB (0.42) | ACHEBCHEMAOBMAOAAHR | |
| SCHEMBL11288733 | 0.91 | MAOB (0.42) | ACHEBCHEMAOBMAOAHRH3 | |
| Hydrochloric Acid SCHEMBL11093431 | 0.89 | MAOB (0.44) | ACHEBCHEMAOBMAOAHRH3 | |
| Bromide SCHEMBL11090702 | 0.87 | MAOB (0.39) | ACHEBCHEMAOBMAOAHRH3 | |
| Bromide SCHEMBL11089271 | 0.87 | MAOB (0.40) | ACHEMAOBMAOAHRH3 | |
| Hydrochloric Acid SCHEMBL11097325 | 0.86 | ACHE (0.39) | ACHEBCHEMAOBMEN1RAB9A | |
| Hydrochloric Acid SCHEMBL11089157 | 0.86 | CA12 (0.40) | ACHEBCHEMAOBMEN1RAB9A | |
| SCHEMBL11294334 | 0.85 | ACHE (0.39) | ACHEBCHEMAOBMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |