Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266270 | 0.89 | KDM4E (0.43) | KDM4EALDH1A1GAAPKMPTAFR | |
| SCHEMBL11083819 | 0.83 | ALPG (0.47) | KDM4EALDH1A1GAAPKMPTAFR | |
| SCHEMBL11267882 | 0.82 | PTGS2 (0.44) | KDM4EALDH1A1HPGDPTGS2SMN1; SMN2 | |
| SCHEMBL11085352 | 0.80 | ALPG (0.40) | PTAFRAKR1B1TBXAS1ALPG | |
| SCHEMBL11082982 | 0.80 | AKR1C3 (0.44) | KDM4EALDH1A1PTAFRTBXAS1HPGD | |
| SCHEMBL11272438 | 0.80 | ALPG (0.56) | KDM4EALDH1A1PTAFRPOLBTBXAS1 | |
| SCHEMBL11548199 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1GAAPKMTP53 | |
| SCHEMBL11090785 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1PTAFRTBXAS1HPGD | |
| SCHEMBL11084425 | 0.77 | ALPG (0.46) | PTAFRTBXAS1ALPG | |
| SCHEMBL11076242 | 0.77 | ALPG (0.64) | PTAFRAKR1B1TBXAS1ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011142-A1 | Pyrido (2,1-b) quinazolinones, their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-05-28 | — | — | EP | claimed |
| US-4457927-A | Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof | SCHERING, AKTIENGESELLSCHAFT (DE) | 1984-07-03 | — | — | US | disclosed |