Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.72 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 3/20 | 0.54 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carazolol SCHEMBL77903 | 0.84 | ADRB2 (1.00) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| Carazolol SCHEMBL6511163 | 0.84 | ADRB2 (1.00) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| Carazolol SCHEMBL77901 | 0.84 | ADRB2 (1.00) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| Carazolol SCHEMBL29354289 | 0.84 | ADRB2 (1.00) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| Carazolol SCHEMBL7530148 | 0.83 | ADRB2 (0.98) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| Carazolol SCHEMBL10568418 | 0.83 | ADRB2 (0.98) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| 4-Hydroxypropranolol Sulfate SCHEMBL28716845 | 0.80 | CYP2D6 (0.72) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| SCHEMBL13495721 | 0.78 | ADRB2 (0.76) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| SCHEMBL12629107 | 0.77 | ADRB2 (0.74) | ADRB2DNM1HTR1ADRD3ADRA2A | |
| SCHEMBL12407602 | 0.77 | ADRB2 (0.74) | ADRB2DNM1HTR1ADRD3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114048-A2 | Use of D,L and D-carazolole for the manufacture of antiglaucoma agents and pharmaceutical compositions containing D-carazolole | Roche Diagnostics GmbH (DE) | 1984-07-25 | — | — | EP | disclosed |