Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10780990 | 0.84 | MTTP (0.39) | MTTPASAH1EPHX1ALDH1A1HTT | |
| SCHEMBL6648109 | 0.80 | TSHR (0.44) | MTTPASAH1KMT2AHTT | |
| SCHEMBL6648420 | 0.77 | PDK2 (0.45) | MTTPASAH1NAAA | |
| SCHEMBL11208949 | 0.75 | SIGMAR1 (0.41) | MTTPASAH1NAAA | |
| SCHEMBL11091963 | 0.75 | GAA (0.44) | GAAKMT2AALDH1A1HTT | |
| SCHEMBL5863509 | 0.73 | MTTP (0.41) | MTTPALDH1A1 | |
| SCHEMBL6649444 | 0.73 | MTTP (0.49) | MTTP | |
| Isopropylamine SCHEMBL11190763 | 0.72 | MTTP (0.49) | MTTP | |
| SCHEMBL11205330 | 0.72 | SIGMAR1 (0.45) | ASAH1KMT2AEPHX1ALDH1A1HTT | |
| SCHEMBL6766343 | 0.72 | MTTP (0.48) | MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452745-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |