Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 6/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094711 | 0.83 | P2RY1 (0.48) | P2RY1NOTUM | |
| SCHEMBL12716083 | 0.81 | P2RY1 (0.59) | P2RY1 | |
| SCHEMBL11093073 | 0.80 | KMT2A (0.36) | P2RY1NOTUMGRM5 | |
| Hydrochloric Acid SCHEMBL11092564 | 0.78 | P2RY1 (0.46) | P2RY1NOTUM | |
| SCHEMBL1571912 | 0.77 | P2RY1 (0.53) | P2RY1 | |
| SCHEMBL11094298 | 0.74 | CYP3A4 (0.43) | — | |
| SCHEMBL11157904 | 0.73 | LMNA (0.41) | NPY5RGRM5 | |
| SCHEMBL11157901 | 0.73 | LMNA (0.41) | NPY5RGRM5 | |
| SCHEMBL15562916 | 0.72 | ALDH1A1 (0.44) | P2RY1NPY5R | |
| SCHEMBL11095940 | 0.72 | LMNA (0.43) | P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | claimed |
| US-4477667-A | Spiro[indoline-3,4'-piperidine]s and related compounds | AMERICAN HOECHST CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4408050-A | Spiro(indoline-3,4'-piperidine) and related compounds | AMERICAN HOECHST CORPORATION (US) | 1983-10-04 | — | — | US | disclosed |
| US-4379932-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379933-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |