Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089588 | 0.86 | KDM4C (0.50) | KDM4CKDM4ESTAT3HIF1ATSHR | |
| SCHEMBL1009945 | 0.71 | KDM4C (0.52) | KDM4CKDM4ESTAT3HIF1ATSHR | |
| SCHEMBL11093184 | 0.70 | ALDH1A1 (0.50) | KDM4EALDH1A1GAAHPGDALOX15 | |
| SCHEMBL8318770 | 0.70 | HCAR2 (0.44) | KDM4EFLT3ALDH1A1KITALOX15 | |
| SCHEMBL11094727 | 0.69 | ALDH1A1 (0.41) | KDM4ETSHRALDH1A1GAAHPGD | |
| SCHEMBL16453474 | 0.69 | KDM4C (0.53) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL4714263 | 0.68 | KDM4C (0.49) | KDM4CKDM4ESTAT3HIF1ATSHR | |
| SCHEMBL22424292 | 0.68 | KDM4C (0.49) | KDM4CKDM4ESTAT3HIF1ATSHR | |
| SCHEMBL9213204 | 0.68 | KDM4C (0.56) | KDM4CKDM4ESTAT3HIF1ATSHR | |
| SCHEMBL12263262 | 0.67 | HCAR2 (0.55) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-A2 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998011101-A2 | CONDENSED N-ACLYINDOLES AS ANTITUMOR AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-03-19 | — | — | WO | disclosed |