Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.57 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.57 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 11/20 | 0.57 |
| ▸ | THRA | P10827 | 8/20 | 0.57 |
| ▸ | PPARG | P37231 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TTR | P02766 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | RXRA | P19793 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Putrescine SCHEMBL11092650 | 0.96 | THRB (0.55) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL1526069 | 0.96 | THRB (0.59) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL8417806 | 0.96 | THRB (0.59) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL10780803 | 0.96 | THRB (0.59) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL10780866 | 0.93 | THRB (0.57) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL18558000 | 0.92 | THRB (0.55) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL12808939 | 0.87 | THRB (0.56) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL13952218 | 0.87 | ACE (0.50) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL5160323 | 0.87 | ACE (0.58) | PPARGITGB3ITGAVITGA2BACE | |
| SCHEMBL21243772 | 0.87 | ACE (0.58) | PPARGITGB3ITGAVITGA2BACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108403-A2 | Substituted carboxyfluoresceins | ABBOTT LABORATORIES (US) | 1984-05-16 | — | — | EP | disclosed |