Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.59 |
| ▸ | THRA | P10827 | 6/20 | 0.59 |
| ▸ | PPARG | P37231 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | TTR | P02766 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | RXRA | P19793 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1526069 | 1.00 | THRB (0.59) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL10780803 | 1.00 | THRB (0.59) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL18558000 | 0.96 | THRB (0.55) | THRBTHRAPPARGMEN1KMT2A | |
| Ethylenediamine SCHEMBL11090366 | 0.96 | THRB (0.57) | THRBTHRAPPARGMEN1KMT2A | |
| Putrescine SCHEMBL11092650 | 0.94 | THRB (0.55) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL10780866 | 0.93 | THRB (0.57) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL12808939 | 0.91 | THRB (0.56) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL13952218 | 0.91 | ACE (0.50) | THRBTHRAPPARGMEN1KMT2A | |
| SCHEMBL21243772 | 0.91 | ACE (0.58) | PPARGITGB3ITGAVACEITGA2B | |
| SCHEMBL5160323 | 0.91 | ACE (0.58) | PPARGITGB3ITGAVACEITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250325508-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | TECHNION RES & DEV FOUNDATION (IL) | 2025-10-23 | — | — | US | disclosed |
| EP-4618968-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | Technion Research & Development Foundation Limited (IL) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024105677-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2024-05-23 | — | — | WO | disclosed |
| CN-117279663-A | Antibody drug conjugate comprising antibody against human CLDN18.2 and use thereof | 乐高化学生物科学股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116406294-A | Tyrosine, tryptophan and phenylalanine as mTOR agonists modulating proteasome kinetics, compositions, methods and uses thereof in therapy, and methods of prognosis of drug resistance | 技术研发基金会有限公司 | 2023-07-07 | — | — | CN | disclosed |
| EP-4178563-A1 | TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS MTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE | Technion Research & Development Foundation Ltd. (IL) | 2023-05-17 | — | — | EP | disclosed |
| WO-2023078464-A1 | EPSILON-POLY-L-LYSINE-BASED DRUG CONJUGATE, INTERMEDIATE THEREOF, AND APPLICATION THEREOF | 上海弼领生物技术有限公司 | 2023-05-11 | — | — | WO | disclosed |
| WO-2022185319-A1 | UBIQUITIN LIGASE KPC1-PEPTIDE BASED PROTEOLYSIS TARGETING CHIMERAS (PROTAC) AND USES THEREOF | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2022-09-09 | — | — | WO | disclosed |
| EP-1105730-B1 | ENZYME INHIBITION IMMUNOASSAY | ROCHE DIAGNOSTICS OPERATIONS (US) | 2008-01-23 | — | — | EP | disclosed |
| US-5986094-A | XANTHENE DYES AND PHTHALEIN DYES FOR FLUORESCEENT DYES | ROCHE DIAGNOSTICS CORPORATION (US) | 1999-11-16 | — | — | US | disclosed |
| US-4786591-A | HETEROGENEOUS IMMUNOASSAY | BOEHRINGER MANNHEIM GMBH (DE) | 1988-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250325508-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | PSMC1, PSME3, PSMA6 | THRB 2147/4885THRA 3519/4885PPARG 3376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.