Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MTHFD2 | P13995 | 4/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11092323 | 0.87 | CDK1 (0.50) | PTGS1MTHFD2PTGDR2CYP2C9KCNK3 | |
| SCHEMBL11090704 | 0.84 | PTGS1 (0.50) | PTGS1MTHFD2PTGDR2CYP2C9CFTR | |
| SCHEMBL11087511 | 0.78 | LMNA (0.40) | PTGDR2BLM | |
| SCHEMBL11088759 | 0.76 | ADORA3 (0.43) | CYP2C9 | |
| Ether SCHEMBL11832353 | 0.75 | HTR2C (0.38) | CYP2C9 | |
| SCHEMBL11400880 | 0.75 | PTGS1 (0.50) | PTGS1MTHFD2PTGDR2CYP2C9KCNK3 | |
| SCHEMBL11397662 | 0.72 | PTGS1 (0.58) | PTGS1MTHFD2PTGDR2CYP2C9KCNK3 | |
| SCHEMBL12386800 | 0.72 | PTGDR2 (0.49) | MTHFD2PTGDR2CYP2C9BLMKCNK3 | |
| SCHEMBL11088651 | 0.72 | PTGS1 (0.68) | PTGS1 | |
| SCHEMBL10313025 | 0.70 | PTGS1 (0.47) | PTGS1MTHFD2PTGDR2CYP2C9BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478837-A | HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1984-10-23 | — | — | US | disclosed |
| US-3954754-A | ANTIHYPERTENSIVES | SANDOZ LTD. (CH) | 1976-05-04 | — | — | US | disclosed |