Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.76 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.76 |
| ▸ | DRD2 | P14416 | 10/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270088 | 0.97 | SIGMAR1 (0.81) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| Maleic Acid SCHEMBL11088205 | 0.92 | SIGMAR1 (0.72) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| Fumaric Acid SCHEMBL11088213 | 0.92 | SIGMAR1 (0.72) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| SCHEMBL11475634 | 0.87 | SIGMAR1 (1.00) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| SCHEMBL11480152 | 0.82 | SIGMAR1 (0.83) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL11481362 | 0.82 | SIGMAR1 (0.81) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| SCHEMBL11473027 | 0.76 | SLC18A3 (0.69) | SIGMAR1SLC18A3DRD2HTR2ATSHR | |
| SCHEMBL11474458 | 0.76 | SIGMAR1 (0.63) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| SCHEMBL9052827 | 0.74 | DRD2 (0.80) | SIGMAR1SLC18A3DRD2HTR2AHTR2B | |
| SCHEMBL11085101 | 0.74 | AKT1 (0.49) | SIGMAR1SLC18A3ADRA2CNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4477667-A | Spiro[indoline-3,4'-piperidine]s and related compounds | AMERICAN HOECHST CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4408050-A | Spiro(indoline-3,4'-piperidine) and related compounds | AMERICAN HOECHST CORPORATION (US) | 1983-10-04 | — | — | US | disclosed |
| US-4379932-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379933-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | disclosed |