Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.63 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HLA-A | P04439 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11473027 | 0.87 | SLC18A3 (0.69) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| SCHEMBL11471106 | 0.84 | SLC18A3 (0.66) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| SCHEMBL11482119 | 0.83 | SLC18A3 (0.64) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| SCHEMBL11474306 | 0.81 | SLC18A3 (0.60) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| SCHEMBL11743201 | 0.80 | DRD2 (0.80) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL11474361 | 0.80 | SIGMAR1 (0.59) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| SCHEMBL11475634 | 0.77 | SIGMAR1 (1.00) | SIGMAR1SLC18A3DRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL11394275 | 0.76 | DRD2 (0.62) | SIGMAR1SLC18A3DRD2HTR2ADRD3 | |
| Mespiperone SCHEMBL1901596 | 0.76 | DRD2 (1.00) | SIGMAR1DRD2DRD4HTR2ADRD3 | |
| SCHEMBL11270088 | 0.76 | SIGMAR1 (0.81) | SIGMAR1SLC18A3DRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4233307-A | Spiro-4'-piperidine compounds and their pharmaceutical compositions | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-11-11 | — | — | US | disclosed |