Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064315 | 1.00 | MCHR1 (0.46) | MCHR1HDAC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL10286659 | 1.00 | MCHR1 (0.46) | MCHR1HDAC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL12056015 | 0.92 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL401077 | 0.92 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL405359 | 0.92 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL1912171 | 0.88 | ALDH1A1 (0.43) | ALDH1A1MAPTTDP1L3MBTL1LMNA | |
| SCHEMBL1912172 | 0.86 | MCHR1 (0.48) | MCHR1HDAC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL1912163 | 0.85 | HDAC1 (0.55) | MCHR1HDAC1 | |
| SCHEMBL1109294 | 0.85 | HDAC1 (0.55) | MCHR1HDAC1 | |
| SCHEMBL1912207 | 0.85 | ALDH1A1 (0.41) | MCHR1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153843-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2012-04-10 | — | — | US | disclosed |
| US-7989660-B2 | BACTERICIDE AGAINST GRAMNEGATIVE BACTERIA; RESPIARATORY SYSTEM DISORDERS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100324025-A1 | Antibacterial Agents | UNIVERSITY OF WASHINGTON (US) | 2010-12-23 | — | — | US | disclosed |
| US-20090247506-A1 | Antibacterial agents | CHIRON CORPORATION | 2009-10-01 | — | — | US | disclosed |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2008-10-30 | — | — | US | disclosed |
| US-7358359-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2008-04-15 | — | — | US | disclosed |
| US-20070244197-A1 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244197-A1 | Antibacterial agents | MRPL21, SI, PGLS | MCHR1 4181/4885HDAC1 824/4885ALDH1A1 782/4885 |
| US-20090247506-A1 | Antibacterial agents | MRPL21, SI, PGLS | MCHR1 4181/4885HDAC1 824/4885ALDH1A1 782/4885 |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | MCHR1 4181/4885HDAC1 824/4885ALDH1A1 782/4885 |
| US-20100324025-A1 | Antibacterial Agents | MRPL21, SI, PGLS | MCHR1 4181/4885HDAC1 824/4885ALDH1A1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.