Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 13/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088793 | 0.84 | OPRK1 (0.46) | OPRK1PDE4DAVPR1AMAPTTHRB | |
| SCHEMBL11092588 | 0.83 | OPRK1 (0.43) | OPRK1PDE4DAVPR1AMAPTTHRB | |
| SCHEMBL11719260 | 0.72 | AVPR1A (0.35) | OPRK1PDE4DTRPM5AVPR1AKCNH2 | |
| SCHEMBL11089558 | 0.68 | TRPM5 (0.43) | OPRK1PDE4DTRPM5MAPTGFER | |
| SCHEMBL11713116 | 0.68 | KMT2A (0.34) | OPRK1PDE4DTRPM5AVPR1AKCNH2 | |
| SCHEMBL7436839 | 0.68 | OPRK1 (0.73) | OPRK1PDE4DKCNH2 | |
| SCHEMBL11083893 | 0.66 | MAPT (0.38) | OPRK1PDE4DMAPTTHRBKCNH2 | |
| SCHEMBL11086276 | 0.63 | TDP1 (0.46) | OPRK1PDE4DAVPR1A | |
| SCHEMBL11083553 | 0.63 | BRD4 (0.47) | OPRK1PDE4D | |
| SCHEMBL11442659 | 0.63 | OPRK1 (0.38) | OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476133-A | CENTRAL NERVOUS SYSTEM DISORDERS | SHIONOGI & CO., LTD. (JP) | 1984-10-09 | — | — | US | disclosed |
| US-4374842-A | CENTRAL NERVOUS SYSTEM | SHIONOGI & CO., LTD. (JP) | 1983-02-22 | — | — | US | disclosed |