Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089084 | 0.95 | KDM4E (0.41) | KDM4EALDH1A1HTR1BNR2E1RAB9A | |
| SCHEMBL17445904 | 0.81 | PDK2 (0.46) | KDM4EALDH1A1RAB9APKMLMNA | |
| SCHEMBL11094297 | 0.81 | PDK2 (0.45) | KDM4EHTR1BRAB9APKMLMNA | |
| SCHEMBL11474185 | 0.79 | CYP1A2 (0.39) | KDM4ERAB9APKMLMNACYP1A2 | |
| SCHEMBL11086343 | 0.77 | KDM4E (0.37) | KDM4EALDH1A1HTR1BNR2E1CACNA2D1 | |
| SCHEMBL11204381 | 0.76 | PDK2 (0.37) | KDM4EALDH1A1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL11478909 | 0.76 | MTTP (0.44) | KDM4EALDH1A1 | |
| SCHEMBL10774863 | 0.75 | RAB9A (0.39) | KDM4EALDH1A1RAB9APKMLMNA | |
| SCHEMBL7322958 | 0.74 | CYP1A2 (0.45) | KDM4ERAB9APKMLMNAATM | |
| SCHEMBL11205330 | 0.74 | SIGMAR1 (0.45) | KDM4EALDH1A1PKMCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452745-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |