Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094372 | 0.85 | PDE4B (0.37) | — | |
| SCHEMBL11095940 | 0.82 | LMNA (0.43) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11094298 | 0.81 | CYP3A4 (0.43) | L3MBTL1LMNASMN1; SMN2ENPP2MAPK1 | |
| Maleic Acid SCHEMBL11093046 | 0.80 | MAPT (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| Fumaric Acid SCHEMBL11093052 | 0.80 | MAPT (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11157904 | 0.80 | LMNA (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11157901 | 0.80 | LMNA (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11090757 | 0.80 | OTUD7B (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11094039 | 0.79 | LMNA (0.41) | L3MBTL1LMNASMN1; SMN2MAPTENPP2 | |
| SCHEMBL11094339 | 0.77 | NPY5R (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | claimed |
| US-4477667-A | Spiro[indoline-3,4'-piperidine]s and related compounds | AMERICAN HOECHST CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | disclosed |