Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | PTAFR | P25105 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403813 | 0.92 | HIF1A (0.45) | ADRB1ADRB3ADRB2HDAC1NAMPT | |
| SCHEMBL1109377 | 0.91 | HTT (0.48) | ADRB1ADRB3ADRB2HDAC1NAMPT | |
| SCHEMBL1109465 | 0.89 | HDAC2 (0.43) | ADRB1ADRB3ADRB2HDAC1NAMPT | |
| SCHEMBL1109480 | 0.89 | HDAC1 (0.54) | ADRB1ADRB3ADRB2HDAC1CTSB | |
| SCHEMBL1109317 | 0.85 | ADRB1 (0.47) | ADRB1ADRB3ADRB2HDAC1PTAFR | |
| SCHEMBL1109509 | 0.84 | NAMPT (0.47) | HDAC1NAMPTCTSLCTSBCTSS | |
| SCHEMBL1109340 | 0.84 | NAMPT (0.44) | HDAC1NAMPTHDAC2USP30 | |
| SCHEMBL1109234 | 0.84 | ANPEP (0.39) | HDAC1HDAC2HTT | |
| SCHEMBL1109166 | 0.84 | MEN1 (0.45) | ADRB1ADRB3ADRB2HDAC1NAMPT | |
| SCHEMBL1912226 | 0.84 | HDAC1 (0.48) | HDAC1NAMPTHDAC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153843-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2012-04-10 | — | — | US | disclosed |
| US-8101640-B2 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8084615-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2011-12-27 | — | — | US | disclosed |
| US-7989660-B2 | BACTERICIDE AGAINST GRAMNEGATIVE BACTERIA; RESPIARATORY SYSTEM DISORDERS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20110172174-A1 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS INC. | 2011-07-14 | — | — | US | disclosed |
| US-20100324025-A1 | Antibacterial Agents | UNIVERSITY OF WASHINGTON (US) | 2010-12-23 | — | — | US | disclosed |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | UNIVERSITY OF WASHINGTON (US) | 2009-06-25 | — | — | US | disclosed |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2008-10-30 | — | — | US | disclosed |
| US-20070244197-A1 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244197-A1 | Antibacterial agents | MRPL21, SI, PGLS | ADRB1 1968/4885ADRB3 3223/4885ADRB2 2728/4885 |
| US-20110172174-A1 | Antibacterial agents | MRPL21, SI, PGLS | ADRB1 1968/4885ADRB3 3223/4885ADRB2 2728/4885 |
| US-20080269221-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | ADRB1 1968/4885ADRB3 3223/4885ADRB2 2728/4885 |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | ADRB1 1968/4885ADRB3 3223/4885ADRB2 2728/4885 |
| US-20100324025-A1 | Antibacterial Agents | MRPL21, SI, PGLS | ADRB1 1968/4885ADRB3 3223/4885ADRB2 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.