Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749384 | 0.87 | KCNN4 (0.41) | MAOAMAOBNPC1RAB9AFFAR1 | |
| SCHEMBL6139367 | 0.87 | TSHR (0.38) | MAOAMAOBFFAR1ALDH1A1ESR1 | |
| SCHEMBL11066784 | 0.82 | MIF (0.47) | NPC1FFAR1ALDH1A1ESR1CYP3A4 | |
| SCHEMBL7749391 | 0.81 | MIF (0.37) | MAOAMAOBFFAR1ALDH1A1ESR1 | |
| SCHEMBL7825477 | 0.81 | KCNN4 (0.38) | MAOAMAOBNPC1RAB9AFFAR1 | |
| SCHEMBL6139488 | 0.80 | KIF11 (0.35) | FFAR1FFAR4ALDH1A1ESR1CYP3A4 | |
| SCHEMBL7953170 | 0.80 | KIF11 (0.35) | FFAR1FFAR4ALDH1A1ESR1CYP3A4 | |
| SCHEMBL8180989 | 0.80 | KIF11 (0.40) | ALDH1A1TSHR | |
| SCHEMBL11097461 | 0.79 | FFAR1 (0.41) | NPC1RAB9AFFAR1FFAR4ALDH1A1 | |
| SCHEMBL7957554 | 0.79 | SLC6A2 (0.32) | FFAR1ALDH1A1ESR1CYP3A4ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |