SCHEMBL11097461

SCHEMBL11097461

N#CC(CCC(=O)O)(CCC(=O)O)c1ccc(F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.41
ALDH1A1 P00352 2/20 0.40
ESR1 P03372 1/20 0.40
CYP3A4 P08684 1/20 0.40
ESR2 Q92731 1/20 0.40
CTSL P07711 4/20 0.39
HTT P42858 1/20 0.38
KCNN4 O15554 3/20 0.38
HSD11B1 P28845 1/20 0.36
LMNA P02545 1/20 0.36
CHEK1 O14757 1/20 0.35
FYN P06241 1/20 0.35
PDGFRB P09619 1/20 0.35
PIM1 P11309 1/20 0.35
FGFR1 P11362 1/20 0.35
FLT1 P17948 1/20 0.35
GRK5 P34947 1/20 0.35
MAP2K2 P36507 1/20 0.35
MAPK8 P45983 1/20 0.35
CDK8 P49336 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11821376 0.86 ALDH1A1 (0.39) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11075302 0.84 CYP2C19 (0.40) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11095038 0.83 ALDH1A1 (0.44) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11091213 0.83 ALDH1A1 (0.40) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11066784 0.83 MIF (0.47) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL7749384 0.83 KCNN4 (0.41) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11821360 0.81 CA12 (0.41) ALDH1A1CTSLHTTLMNANPC1
SCHEMBL11821371 0.81 CTSL (0.38) ALDH1A1ESR1CYP3A4ESR2CTSL
SCHEMBL11091478 0.80 NPC1 (0.46) FFAR1ALDH1A1ESR1CYP3A4ESR2
SCHEMBL11095066 0.79 MAOA (0.37) FFAR1ALDH1A1ESR1CYP3A4ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4460604-A ANALGESICS, NARCOTIC ANTAGONIST THE UPJOHN COMPANY (US) 1984-07-17 US disclosed
US-4180584-A ANALGESIC; NARCOTIC ANTAGONIST THE UPJOHN COMPANY (US) 1979-12-25 US disclosed
US-4065573-A ANALGESICS THE UPJOHN COMPANY (US) 1977-12-27 US disclosed