Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749384 | 0.93 | KCNN4 (0.41) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL7752049 | 0.87 | CASP1 (0.34) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL7744793 | 0.83 | HSD17B10 (0.38) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL7744784 | 0.81 | SMN1; SMN2 (0.34) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL8121805 | 0.81 | KCNN4 (0.33) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL11095066 | 0.81 | MAOA (0.37) | ALDH1A1ESR1CYP3A4ESR2MIF | |
| SCHEMBL7749391 | 0.81 | MIF (0.37) | ALDH1A1ESR1CYP3A4ESR2MIF | |
| SCHEMBL11823228 | 0.80 | KCNN4 (0.33) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL7749357 | 0.80 | MAPT (0.35) | KCNN4ALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL7752046 | 0.79 | RORC (0.36) | KCNN4ALDH1A1CYP3A4HSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888304-B1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI SYNTHELABO (FR) | 2001-10-04 | — | — | EP | disclosed |
| EP-0888304-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032852-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1997-09-12 | — | — | WO | disclosed |